1. CANCEROMICS: CANCER GENOMICS AND PROTEOMICS
Using Functional Genomics and Proteomics approaches to elucidate genes and proteins with differential expression in cancer cells. Identification of new markers with prognostic or diagnostic value in clinic.
2. MOLECULAR BIOLOGY OF CANCER
Amino acid regulation of gene expression in cancer cells. New anti-cancer therapeutic strategies based on antisense technology and RNAi targeting glutaminase. Wnt-beta catenin signalling pathways in tumours. Molecular portrait of glutaminase expression in human cancer tissues.
3. NEUROCHEMISTRY: CELLULAR AND MOLECULAR MECHANISMS IN GLUTAMATERGIC TRANSMISSION
Expression of glutaminase K and L isoforms in mammalian brain. New functions of glutaminase and potential involvement in altered neurological states and neurodegenerative diseases. Development of transgenic mouse models with altered glutamine/glutamate cycle in brain.
4. GLUTAMINASE EXPRESSION IN MAMMALIAN TISSUES
Patterns of glutaminase expression in mammalian tissues and cells. Biological roles of glutaminase isoenzymes. Protein-Protein interactions between PDZ-domain proteins and glutaminase. Structure/function studies of human glutaminases.