Papers & Book Chapters

Anso, E, Mullen, A.R., Felsher, D.W., Matés, J.M., DeBerardinis, R.J., Chandel, N.S. Metabolic changes in cancer cells upon suppression of myc. Cancer & Metabolism 1:7 (2013).

Szeliga M, Bogacińska-Karaś M, Różycka A, Hilgier W, Marquez J, Albrecht J. Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells. Tumour Biol. 2013 Oct 6. PMID: 24096582.

Ruiz-Pérez, M.V., Sánchez-Jiménez, F., Alonso, F.J., Segura, J.A., Márquez, J.  Glutamine, Glucose and other Fuels for Cancer. Curr Pharm Des. 2013 Jun 25. [Epub ahead of print] PMID: 23859613

Márquez, J., Cardona, C., Campos-Sandoval, J.A., Peñalver, A., Tosina, M., Matés, J.M., Martín-Rufián, M. Mammalian glutaminase isozymes in brain. Metab. Brain Dis. 28: 133-137 (2013) Download

Matés, J.M., Segura, J.A., Martín-Rufián, M., Campos-Sandoval, J.A., Alonso, F.J., Márquez, J. Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer. Current Molecular Medicine 13 (4): 514-534 (2013)

Yuneva, M.O., Fan, T.W.M., Allen, T.D., Higashi, R.M., Ferraris, D.V., Tsukamoto, T., Matés, J.M., Alonso, F.J., Wang, C., Seo, Y., Chen, X., Bishop, J.M. The metabolic profile of tumors can vary with both a responsible genetic lesion and tissue of origin. Cell Metabolism, 15, 157-170 (2012).

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X.L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., Cai, L., Good, L., Tu, B.P., Hatanpaa, K.J., Mickey, B.E., Matés, J.M., Pascual, J.M., Maher, E.A., Malloy, C.R., DeBerardinis, R.J., Bachoo, R.M. In vivo analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain. Cell Metabolism, 15, 827-837 (2012).

Bae, N., Yang, J-W., Sitte, H., Pollak, A., Márquez, J., Lubec, G. An electrophoretic approach to screen for glutamine deamidation. Anal. Biochem. 428: 1-3 (2012) Download

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Oxidative stress in apoptosis and cancer: an update. Arch. Toxicol. 86, 1649-1665 (2012)

Martín-Rufián, M., Tosina, M., Campos-Sandoval, J.A., Manzanares, E., Lobo, C., Segura, J.A., Alonso, F.J., Matés, J.M., Márquez, J. Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism. PLoS ONE 7(6):e38380 (2012) Download

Blanco, E., Bilbao, A., Luque-Rojas, M.J., Palomino, A., Bermúdez-Silva, F.J., Suárez, J., Santín, L.J., Estivill-Torrús, G., Gutiérrez, A., Campos-Sandoval, J.A., Alonso-Carrión, F.J., Márquez, J., de Fonseca, F.R. Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors. Psychopharmacology 220: 27-42 (2012) Download

Blanco, E., Campos-Sandoval, J.A., Palomino, A., Luque-Rojas, M.J., Bilbao, A., Márquez, J., de Fonseca, F.R. Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice. Psychopharmacology 219: 933-44 (2012)  Download

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Sulphur-containing non enzymatic antioxidants: therapeutic tools against cancer. Front. Biosci. 4, 722-748 (2012)

Yuneva, M.O., Fan, T.W.M., Allen, T.D., Higashi, R.M., Ferraris, D.V., Tsukamoto, T., Matés, J.M., Alonso, F.J., Wang, C., Seo, Y., Chen, X., Bishop, J.M. The metabolic profile of tumors can vary with both a responsible genetic lesion and tissue of origin. Cell Metabolism, 15, 157-170 (2012).

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X.L., Rajagopalan, K.N., Maddie, M., Vemireddy, V., Zhao, Z., Cai, L., Good, L., Tu, B.P., Hatanpaa, K.J., Mickey, B.E., Matés, J.M., Pascual, J.M., Maher, E.A., Malloy, C.R., DeBerardinis, R.J., Bachoo, R.M. In vivo analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain. Cell Metabolism, 15, 827-837 (2012) Download

Matés, J.M., Segura, J.A., Alonso, F.J, Márquez, J. Anticancer antioxidant regulatory functions of phytochemicals. Curr. Med. Chem. 18, 2315-2338 (2011)

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Glutaminase (Book chapter). Amino Acids in Human Nutrition and Health. Edited by F. D´Mello. CABI, Wallingford (UK), pp 122-136 (2011) ISBN 978-1-84593-798-0

Cheng, T., Sudderth, J., Yang, C., Mullen, A.R., Jin, E.S., Matés, J.M., DeBerardinis, R.J. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proceedings of the National Academy of Sciences, USA. 108, 8674-8679 (2011)

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Role of dioxins and heavy metals in cancer and neurological diseases by ROS-mediated mechanisms. Free Rad. Biol. Med. 49, 1328-1341 (2010)

Márquez, J., Matés, J.M., Segura, J.A., Campos-Sandoval, J.A., Lobo, C., Alonso, F.J. Brain glutaminases. Biomol. Concepts 1, 3-15 (2010)

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Oxidative stress and apoptosis (Book Chapter). Apoptosis; Series: Modern Insights Into Disease from Molecules to Man. Ed. V.R. Preedy. Science Publishers & CRC Press, New Hampshire (USA), pp 241-256 (2010) ISBN 978-1-57808-583-5

Matés, J.M., Segura, J.A., Campos-Sandoval, J.A., Lobo, C., Alonso, L., Alonso, F.J., Márquez, J. Glutamine homeostasis and mitochondrial dynamics. Int. J. Biochem. Cell Biol. 41, 2051-2061 (2009) Download

De la Rosa, V., Campos-Sandoval, J.A., Martín-Rufián, M., Cardona, C., Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. A novel glutaminase isoform in mammalian tissues. Neurochem. Int. 55, 76-84 (2009)

Márquez, J., Tosina, M., de la Rosa, V., Segura, J.A., Alonso, F.J., Matés, J.M., Campos-Sandoval, J.A. New insights into brain glutaminases: Beyond their role on glutamatergic transmission. Neurochem. Int. 55, 64-70 (2009)

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Natural antioxidants: therapeutic prospects for cancer and neurological diseases. Mini-Reviews in Medicinal Chemistry 9, 1202-1214 (2009)

Szeliga M, Obara-Michlewska M, Matyja E, Lazarczyk M, Lobo C, Hilgier W, Alonso FJ, Márquez J, Albrecht J. Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells. Glia 57, 1014-1023 (2009) Download

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Natural antioxidants: therapeutic prospects for cancer and neurological diseases. Arch. Toxicol. 82, 273-299 (2008)

Banerjee, M., Huang, C., Marquez, J., Mohanty, S. Probing the Structure and Function of Human Glutaminase-Interacting Protein: A Possible Target for Drug Design. Biochemistry 47, 9208-9219 (2008) Download

Matés, J.M., Segura, J.A., Alonso, F.J., Márquez, J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis and carcinogenesis. Arch. Toxicol. 82, 273-299 (2008)

Olalla, L., Gutiérrez, A., Jiménez, A.J., López-Téllez, J.F., Khan, Z.U., Pérez, J., Alonso, F.J., de la Rosa, V., Campos-Sandoval, J.A., Segura, J.A., Aledo, J.C., Márquez, J. Expression of Scaffolding PDZ Protein GIP (Glutaminase-Interacting-Protein) in Mammalian Brain. J. Neurosci. Res. 86, 281-292 (2008)

Donadio, A.C., Lobo, C., Tosina, M., de la Rosa, V., Martín-Rufián, M., Campos-Sandoval, J.A., Matés, J.M., Márquez, J., Alonso, F.J., Segura, J.A. Antisense glutaminase inhibition modifies the O-GlcNac pattern and flux through the hexosamine pathway in breast cancer cells. J. Cell. Biochem. 103, 800-811 (2008)

J.A. Campos-Sandoval, A. R. López de la Oliva. J.A. Segura, J.M. Matés, F.J. Alonso, J. Márquez. EXPRESSION OF FUNCTIONAL HUMAN GLUTAMINASE IN BACULOVIRUS SYSTEM. NOVEL AFFINITY PURIFICATION, KINETIC AND MOLECULAR CHARACTERIZATION. The International Journal of Biochemistry and Cell Biology, 39, 765-773 (2007) Download

J. Márquez, A.R. López de la Oliva, J.M.  Matés, J.A. Segura, F.J. Alonso. GLUTAMINASE: A MULTIFACETED PROTEIN NOT ONLY INVOLVED IN GENERATING GLUTAMATE. Neurochemistry International, 48, 465-471 (2006) Download

Carraro, S., Doherty, J., Zaman, K., Gainov, I., Turner, R., Vaughan, J., Hunt, J.F., Márquez, J., Gaston, B. S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L827-L832 (2006) Download

J.M. Matés, J. Segura, F. Alonso, J. Márquez. PATHWAYS FROM GLUTAMINE TO APOPTOSIS. Frontiers in Bioscience, 11, 3164-3170 (2006).

J.A. Cornejo, C. Mayorga, M.J. Torres, T.D. Fernández, R. R-Pena, I. Bravo, J.M. Matés, M. Blanca. ANTI-OXIDANT ENZYME ACTIVITIES AND EXPRESSION AND OXIDATIVE DAMAGE IN PATIENTS WITH NON-IMMEDIATE REACTIONS TO DRUGS. Clinical and Experimental Immunology, 145, 287-295 (2006).

Martín-Rufián, M., Segura, Lobo, C., Matés, J.M., Márquez, J., Alonso, F.J. Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by Differential Display. Cancer Biol. Ther. 5, e1-e5 (2006) Download

Alonso, F.J., Segura, J.A., Lora, J., Lobo, C., Fernández-Molina, B., Márquez, J., Matés, J.M. Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase. Anticancer Res. 25, 3315-3320 (2005)

Segura, J.A., Donadio, A.C., Lobo, C., Matés, J.M., Márquez, J., Alonso, F.J. Inhibition of glutaminase expression increases Sp1 phosphorylation and Sp1/Sp3 transcriptional activity in Ehrlich tumor cells. Cancer Lett. 218, 91-98 (2005)

Pérez-Gómez, C., Campos-Sandoval, J.A., Alonso, F.J., Segura, J.A., Manzanares, E., Ruiz-Sánchez, P., González, M.E., Márquez, J., Matés, J.M. Coexpression of glutaminase K and L isozymes in human tumour cells. Biochem. J. 385, 1-8 (2005)

Lora, J., Alonso, F.J., Segura, J.A., Lobo, C., Márquez, J., Matés, J.M. Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells. Eur. J. Biochem. 271, 4298-4306 (2004)

Castell, L., Vance C., Abbott R, Márquez, J., Eggleton, P. Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity. J. Biol. Chem. 279, 13305-13310 (2004) Download

Campos, J.A., Aledo, J.C., Segura, J.A., Alonso, F.J., Gómez-Fabre, P.M., Núñez de Castro, I., Márquez, J. Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues. Biochim. Biophys. Acta 1648, 17-23 (2003) Download

Pérez-Gómez, C., Matés, J.M., Gómez-Fabre, P.M., del Castillo-Olivares, A., Alonso, F.J., Márquez, J. Genomic organization and transcriptional analysis of the human L-glutaminase gene. Biochem. J. 370, 771-784 (2003) Download

Olalla, L., Gutiérrez, A., Campos, J.A., Khan, Z.U., Alonso, F.J., Segura, J.A., Márquez, J., Aledo, J.C. Nuclear localization of L-glutaminase in mammalian brain. J. Biol. Chem. 277, 38939-38944 (2002) Download

Aledo, J.C., Rosado, A., Olalla, L., Campos, J.A., Márquez, J. Overexpression, purification, and characterization of Glutaminase-Interacting Protein, a PDZ-domain protein from human brain. Protein Express. Purif. 23, 411-418 (2001)

Olalla, L., Aledo, J.C., Bannenberg, G., Márquez, J. The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. FEBS Lett. 488, 116-122 (2001)

Segura, J.A., Ruiz Bellido, M.A., Arenas Acrís, M., Lobo, C., Márquez, J., Alonso, F.J. Ehrlich ascites tumor cells expressing antisense glutaminase mRNA loss their capacity to evade the mouse immune system. Int. J. Cancer 91:379-384 (2001)

Aledo, J.C., Gómez-Fabre, P.M., Olalla, L., Márquez, J. Identification of two human glutaminase loci and tissue-specific expression of the two related genes. Mamm. Genome 11:1107-1110 (2000)

Gómez-Fabre, P., Aledo, J.C., del Castillo-Olivares, A., Alonso, F.J., Campos, J.A., Núñez de Castro, I., Márquez, J. Molecular cloning, sequencing and expression studies of the human tumor glutaminase. Biochem. J. 345:365-375 (2000)

Lobo, C., Ruiz-Bellido, M.A., Aledo, J.C., Márquez, J., Núñez de Castro, I. y Alonso, F.J. Inhibition of glutaminase expression by antisense mRNA decreases growth and tumorigenicity of tumor cells. Biochem. J. 348:257-261(2000)

Segura, J.A., Barbero, L.G., Márquez, J. Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation. Immunol. Lett. 74:111-115 (2000)

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